{
  "record": "bindseek-gba1-structure-baseline-001",
  "type": "structural_baseline",
  "target": "Human GBA1 / lysosomal acid glucosylceramidase",
  "accession": "P04062",
  "disease_context": "Gaucher disease",
  "research_question": "Describe residue coverage and confidence of the existing public predicted structure, with UniProt region annotations, as a reproducible structural baseline.",
  "analysis": "BindSeek summary of public structure coordinates and source annotations",
  "structure_origin": "AlphaFold DB predicted structure; not a newly generated BindSeek design",
  "source_structure_id": "AF-P04062-F1",
  "source_structure_version": 6,
  "sequence_length": 536,
  "coordinate_residue_count": 536,
  "coverage_percent": 100.0,
  "mean_ca_plddt": 93.24,
  "low_confidence_residue_count_below_50": 31,
  "below_70_residue_count": 46,
  "at_least_90_residue_count": 472,
  "annotations": [
    {
      "type": "Signal",
      "start": 1,
      "end": 39,
      "description": ""
    },
    {
      "type": "Chain",
      "start": 40,
      "end": 536,
      "description": "Lysosomal acid glucosylceramidase"
    }
  ],
  "created_utc": "2026-11-14T13:14:11.506083+00:00",
  "experimental_validation": false,
  "clinical_interpretation": false,
  "sources": [
    {
      "title": "UniProt P04062",
      "url": "https://rest.uniprot.org/uniprotkb/P04062.json"
    },
    {
      "title": "AlphaFold DB metadata",
      "url": "https://alphafold.ebi.ac.uk/api/prediction/P04062"
    },
    {
      "title": "AlphaFold DB coordinates",
      "url": "https://alphafold.ebi.ac.uk/files/AF-P04062-F1-model_v6.pdb"
    },
    {
      "title": "MedlinePlus Genetics: Gaucher disease",
      "url": "https://medlineplus.gov/genetics/condition/gaucher-disease/"
    }
  ],
  "attribution": "Structure: AlphaFold DB, EMBL-EBI / Google DeepMind, CC BY 4.0. Sequence and annotation: UniProt, CC BY 4.0. Disease background: U.S. National Library of Medicine, MedlinePlus Genetics.",
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    "source-alphafold.json": {
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    "structure.pdb": {
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    "residue-confidence.csv": {
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    "analyze_gba1.py": {
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  "study_objective": "Generate and computationally evaluate new binder candidates against human GBA1. The existing structural baseline is the first completed phase.",
  "study_stage": "structural_baseline_complete",
  "candidate_generation_status": "not_started",
  "updated_utc": "2026-11-14T13:36:05.958283+00:00"
}